To paraphrase the nice American author, Mark Twain, “An excessive amount of of something is dangerous, however an excessive amount of pre-workout is barely sufficient.” Twain initially selected whiskey because the beverage of alternative, however there’s likelihood he’d discover the humor within the near-obsession some modern-day “health” fans have with potent pre-workout concoctions.
Considered use of a pre-workout can actually result in greater depth classes that last more and ship a higher muscle-building, fat-burning stimulus. Nevertheless, all pre-workout formulation are designed with completely different components in numerous doses, so “one scoop” of one thing isn’t at all times similar to “one scoop” of a unique combination.
Understanding what you’re taking, how a lot, and, extra importantly, how your physique reacts to these components is crucial to get the very best outcomes. Earlier than you begin your subsequent coaching session with a high-potency pre-workout, right here’s how you can know the attainable negative effects you may encounter.
Editor’s Word: The next data is supposed to be informative in nature, however shouldn’t be taken as medical recommendation. The content material introduced shouldn’t be meant to be used as analysis, prevention, and/or therapy of well being issues. It’s not an alternative choice to consulting a professional medical skilled.
Pre-Exercise Aspect Results
Most Widespread Pre-Exercise Elements
Pre-workouts are technically a normal class of dietary supplements made up of various mixes with quite a lot of components. Nevertheless, some comparable varieties of components are inclined to pop up throughout completely different formulation.
Stimulants
Presumably probably the most well-known and, for some, most desired, sort of ingredient is a simple stimulant to bolster bodily and psychological vitality. Caffeine, tyrosine, yohimbine, and theacrine are a number of the most typical sources of stimulants.

Whereas the vast majority of pre-workouts comprise some type of stimulant, there are various non-stimulant pre-workout mixes that may be simply as efficient whereas omitting key energizing components.
Blood Stream Enhancers
Many pre-workouts comprise components designed to enhance blood circulation all through the physique. This may also help to enhance “the pump” whereas coaching and will improve endurance. Widespread nitric oxide boosters, typically known as “NO2 boosters,” embody arginine, citrulline, and betaine (to not be confused with beta-alanine, which is an unrelated ingredient with completely different results).
Endurance Help
Many pre-workouts enhance your bodily endurance throughout a coaching session. This could both happen physiologically, by bettering your physique’s capability for sustained output, or by lowering your sense of fatigue so that you basically “really feel much less drained” as a exercise progresses. Widespread endurance boosters embody extremely branched cyclic dextrins (which are literally a carbohydrate supply slightly than a selected complement) and beta-alanine.
Advantages of Pre-Exercise
When it’s time for a pre-workout to deliver results, many formulation knock the ball out of the park. Pre-workouts are standard largely as a result of they’re efficient. Listed here are a number of the most noticeable advantages.
Elevated Vitality and Alertness
Whether or not by stimulants, improved blood stream, or different mechanisms, pre-workouts sometimes get you “fired up” headed right into a coaching session. This may be helpful when you practice after a tiring day at work, when you’re dragging in a sluggish gear earlier than your first repetition, or when you head right into a exercise when your psychological focus is lower than 100%.
Elevated Energy and Power
Pre-workouts can have a direct influence in your energy output throughout a given exercise. (1) By serving to to recruit extra muscle models, thrilling your central nervous system, or bettering your muscle tissue’ skill to contract, pre-workouts could assist to maneuver extra weight for extra reps. Over time, this will contribute to higher strength gains and muscle mass.
Improved Blood Stream
Many pre-workout formulation improve total-body circulation. This improved blood stream could assist with normal alertness and vitality, higher motivation to coach, elevated bodily endurance, and an improved muscle pump. The pump, specifically, has been related to a higher muscle-building stimulus. (2)
Enhanced Endurance
The power to carry out longer exercises with out lowering output has been a time-tested recipe for improved health, energy, and efficiency.

Many pre-workouts assist to enhance endurance throughout a coaching session, both by lowering your physique’s sense of fatigue or by encouraging a sustained energy output. This may be achieved both with improved restoration between units or with higher fueled efficiency at the next depth.
10 Potential Aspect Results
For all of its potential advantages, a pre-workout additionally has the potential to ship some negative effects. No lifter ought to fairly anticipate all achieve for no proverbial “ache” within the gymnasium, whether or not it’s a difficult set or a helpful complement. Listed here are the most typical, although actually not assured, potential points from utilizing a pre-workout.
CNS Burnout
Your central nervous system (CNS) is actually the best way your mind communicates with, and prompts, your muscle tissue throughout train. Your CNS can develop into extra pressured when coaching depth or quantity is elevated, which may negatively have an effect on general restoration and efficiency. (3)
As a result of pre-workouts enable you practice practice more durable and longer — with higher depth and probably extra quantity — chances are you’ll be in danger over overstressing your CNS with extreme use.
Impaired Sleep
Maybe probably the most “apparent” potential downside of a stimulant-laden pre-workout is interrupted sleep and potential insomnia. That is primarily a problem with stimulant-heavy pre-workouts (these which embody caffeine or different stimulants of their formulation), significantly if they’re taken within the afternoon or night.
For instance, taking a pre-workout round 5 p.m. for an afterwork coaching session is more likely to trigger sleep issues than a pre-workout taken at 7 a.m. for an early morning exercise. Nevertheless, particular person sensitivities and complete day by day caffeine consumption (from espresso, tea, soda, and so on.) generally is a issue.
Nausea
Generally easy exhausting coaching can result in nausea. Many skilled lifters have wanted to go to the “puke bucket” throughout high-rep squats, however potent pre-workout formulation may flip even a median exercise right into a bitter abdomen fiasco.
Whether or not it’s as a consequence of an overload of stimulants, an extreme workload, or simply a mixture of varied components swirling round your intestine, a robust pre-workout might go away you feeling queasy, which might finally interrupt your coaching session. Some analysis suggests that is truly one of the crucial widespread negative effects some lifters expertise after taking a pre-workout. (4)
GI Upset
Just like nausea, some lifters could expertise gastric misery (upset abdomen and/or bowel points) after taking a pre-workout, usually as a consequence of high-dose stimulants or associated components. This could severely interrupt a coaching session, usually derailing a exercise earlier than it’s even begun. In excessive instances, it could be extreme sufficient to power a lifter to desert a exercise totally.
Attenuation
Whereas stimulant-based pre-workouts might be extremely efficient for bettering energy, energy, and endurance, they will additionally ship step by step diminishing outcomes if utilized in extra. The physique can develop a tolerance to stimulants, together with caffeine, making their helpful results much less impactful over time. (5)
To make sure most influence, purpose to make use of a pre-workout not more than each different day, slightly than each exercise. When you regularly devour important quantities of caffeine throughout a daily day, think about slicing again or utilizing a pre-workout even much less regularly. This could enable the formulation to ship a extra noticeable profit. (6)
Dehydration
A notable, however comparatively simply preventable, facet impact of pre-workouts is dehydration. By prompting a tougher exercise, some lifters could develop into extra depleted throughout a excessive depth coaching session by way of elevated sweating and the lack of fundamental vitamins. (7)

This will not essentially be accounted for with ample intra-workout hydration. Dehydration can result in an general lower in energy and endurance, making the exercise counterproductive.
Headache
One other attainable facet impact of pre-workout, which can be noticeable sooner slightly than later throughout some classes, is a simple headache. Many pre-workout components improve general blood stream which might be helpful to muscular efficiency, however may also be contraindicated in an individual who’s already experiencing hypertension. (8)
When you’re at the moment coping with hypertension, double-check your pre-workout formulation for components which can exacerbate the problem reminiscent of arginine, citrulline, and different purported “nitric oxide boosters.”
Elevated Coronary heart Charge
Pre-workouts could improve a lifter’s coronary heart price, both comparatively immediately by means of stimulant-based components or by supporting a excessive diploma of coaching depth. In lifters with hypertension or different cardiovascular dangers, an elevated coronary heart price could current a possible hazard.
Whereas train, in itself, could increase an individual’s coronary heart price, the addition of a pre-workout could carry it to inappropriate or sudden ranges.
Pores and skin Response
A comparatively minor facet impact, however no much less distracting, is a “tingling” or itching pores and skin sensation after taking a pre-workout. This may be significantly widespread in formulation which comprise beta-alanine — a complement sometimes related to a “flushing” of the pores and skin.
Some analysis associates the beta-alanine response with an overstimulation of nerve endings, slightly than a symptom of acute allergic response. (9) Regardless, the pores and skin flush could also be distractingly uncomfortable, regardless of being thought of a “profitable signal” that the complement could also be working.
Remedy Interplay
Many dietary dietary supplements carry the chance of potential interactions with prescription drugs. Pre-workout formulation aren’t any completely different and must be approached with satisfactory consideration.
A number of particular person components widespread to pre-workout mixes are thought of “contraindicated” when taking key classes of medicines. For instance, NO2 boosters reminiscent of arginine or citrulline could have an additive impact in folks taking sure drugs for erectile dysfunction. (10)
Equally, the amino acid tyrosine (typically utilized in pre-workouts for improved psychological focus) could work together with sure prescribed antidepressants and will result in elevated blood strain and associated issues.
Pre-Exercise with Care
Pre-workout formulation might be distinctly helpful when used strategically. Nevertheless, like every complement, there are additionally potential negative effects to pay attention to. Mistaking pre-workout formulation as being totally risk-free could be a short-sighted error. Ensure you know what you’re taking and why you’re taking it. Upon getting these particulars sorted out, you’ll be higher ready to anticipate and mitigate any potential negative effects, resulting in higher outcomes general.
References
- Martinez, N., Campbell, B., Franek, M., Buchanan, L., & Colquhoun, R. (2016). The impact of acute pre-workout supplementation on energy and energy efficiency. Journal of the Worldwide Society of Sports activities Vitamin, 13, 29. https://doi.org/10.1186/s12970-016-0138-7
- Schoenfeld, Brad J. PhD, CSCS, CSPS, NSCA-CPT1; Contreras, Bret MA2. The Muscle Pump: Potential Mechanisms and Functions for Enhancing Hypertrophic Variations. Power and Conditioning Journal 36(3):p 21-25, June 2014. | DOI: 10.1097/SSC.0000000000000021
- Zając, A., Chalimoniuk, M., Maszczyk, A., Gołaś, A., & Lngfort, J. (2015). Central and Peripheral Fatigue Throughout Resistance Train – A Vital Evaluate. Journal of human kinetics, 49, 159–169. https://doi.org/10.1515/hukin-2015-0118
- Jagim, A. R., Camic, C. L., & Harty, P. S. (2019). Widespread Habits, Opposed Occasions, and Opinions Concerning Pre-Exercise Complement Use Amongst Common Shoppers. Vitamins, 11(4), 855. https://doi.org/10.3390/nu11040855
- Boulenger, J. P., Patel, J., Submit, R. M., Parma, A. M., & Marangos, P. J. (1983). Persistent caffeine consumption will increase the variety of mind adenosine receptors. Life sciences, 32(10), 1135–1142. https://doi.org/10.1016/0024-3205(83)90119-4
- Addicott, M. A., & Laurienti, P. J. (2009). A comparability of the results of caffeine following abstinence and regular caffeine use. Psychopharmacology, 207(3), 423–431. https://doi.org/10.1007/s00213-009-1668-3
- Choose, L. W., Bellar, D. M., Popp, J. Okay., Craig, B. W., Schoeff, M. A., Hoover, D. L., Fox, B., Kistler, B. M., & Al-Nawaiseh, A. M. (2021). Hydration to Maximize Efficiency and Restoration: Information, Attitudes, and Behaviors Amongst Collegiate Monitor and Subject Throwers. Journal of human kinetics, 79, 111–122. https://doi.org/10.2478/hukin-2021-0065
- Cameron, M., Camic, C. L., Doberstein, S., Erickson, J. L., & Jagim, A. R. (2018). The acute results of a multi-ingredient pre-workout complement on resting vitality expenditure and train efficiency in recreationally lively females. Journal of the Worldwide Society of Sports activities Vitamin, 15, 1. https://doi.org/10.1186/s12970-017-0206-7
- Liu, Q., Sikand, P., Ma, C., Tang, Z., Han, L., Li, Z., Solar, S., LaMotte, R. H., & Dong, X. (2012). Mechanisms of itch evoked by β-alanine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(42), 14532–14537. https://doi.org/10.1523/JNEUROSCI.3509-12.2012
- El-Wakeel, L. M., Fouad, F. A., Saleem, M. D., & Saber-Khalaf, M. (2020). Efficacy and tolerability of sildenafil/l-arginine mixture relative to sildenafil alone in sufferers with natural erectile dysfunction. Andrology, 8(1), 143–147. https://doi.org/10.1111/andr.12671
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